The science already exists. PrEP is highly effective, and antiretroviral therapy can reduce HIV transmission to effectively zero. Yet in 2022, approximately 31,800 Americans acquired HIV, while millions remain disconnected from consistent care due to homelessness, incarceration, untreated mental illness, substance use disorders, stigma, and other structural barriers. Dr. Tyler Evans, CEO of the Wellness Equity Alliance and a physician practicing street medicine, is helping lead efforts to end the HIV epidemic by focusing on individuals often left behind by modern healthcare systems. He discusses why addressing the “last mile” of HIV care requires meeting patients beyond traditional clinic settings. Dr. Evans has held senior leadership roles in government and nonprofit organizations, including serving as New York City’s first Chief Medical Officer during the COVID-19 pandemic and leading infectious disease programs for the AIDS Healthcare Foundation.