Drawing from his experience as Executive Vice President for Medical Affairs at the University of Michigan and CEO of Michigan Medicine, Dr. Marschall Runge examines how technological advances, policy changes, and emerging business models are fundamentally transforming American healthcare. He argues that healthcare stands at a revolutionary inflection point where multiple disruptive forces are reshaping every aspect of care delivery. He systematically analyzes major healthcare disruptors including retail medicine (Amazon, CVS, Walmart), emerging gene and mRNA therapies, artificial intelligence applications, new obesity drugs, and virtual behavioral health platforms. Rather than viewing these changes with alarm, he advocates embracing and directing disruption to address healthcare's core challenges: high costs, limited access, and uneven quality. He currently serves as Dean of the Medical School at the University of Michigan and CEO of Michigan Medicine. With numerous accolades and awards, Dr. Runge has earned a reputation as one of the foremost experts in healthcare innovation.